MyBioSource.com's DOK5 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot. The DOK5 Antibody was generated using Docking Protein 5, and DOK5 as the antigen and it reacts with Human, and Mouse.
Description
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Subunit Structure: Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).
Post-translational Modifications: Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
Similarity: PTB domain mediates receptor interaction. Belongs to the DOK family. Type B subfamily